Requiem for a Dream (2000)

The drug-induced utopias of four Coney Island individuals are shattered when their addictions become stronger.
http://www.imdb.com/title/tt0180093/

Skyfall (2012)

Bond's loyalty to M is tested as her past comes back to haunt her, bringing MI6 under attack.

http://www.imdb.com/title/tt1074638/

And the Band Played On (1993)

The story of the discovery of the AIDS epidemic and the political infighting of the scientific community hampering the early fight with it.

http://www.imdb.com/title/tt0106273/

Breaking the Mould (2009)

A historical drama that tells the story of the development of penicillin in the 1930's/40's, by a group of scientists in Oxford at The Dunn School of Pathology.

http://www.imdb.com/title/tt1434927/